A major challenge of genome-wide association studies (GWASs) is to translate phenotypic
associations into biological insights. Here, we integrate a large GWAS on blood lipids …

Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …

Clinical laboratory tests play a pivotal role in medical decision making, but little is known
about their genetic variability between populations. We report a genome-wide association …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify
risk loci, we perform a meta-analysis of three genome-wide association studies comprising …

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200
genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide …

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar
endo‐and xenobiotics in the human body, especially in the tissue barriers and the …

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney
disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and …

Aims Our objective was to better understand the genetic bases of dilated cardiomyopathy
(DCM), a leading cause of systolic heart failure. Methods and results We conducted the …

Metabolic syndrome (MetS) which is caused by obesity and insulin resistance, is well known
for its predictive capability for the risk of type 2 diabetes mellitus and cardiovascular disease …