Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
Despite advancements in treatment protocols, cancer is one of the leading cause of deaths
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
Biomimetic gland models with engineered stratagems
X Lin, L Sun, M Lu, Y Zhao - Research, 2023 - spj.science.org
As extensively distributed tissues throughout the human body, glands play a critical role in
various physiological processes. Therefore, the construction of biomimetic gland models in …
various physiological processes. Therefore, the construction of biomimetic gland models in …
Translational pharmacokinetic/pharmacodynamic modeling and simulation of oxaliplatin and irinotecan in colorectal cancer
J Zhu, Y Zhang, Y Zhao, J Zhang, K Hao, H He - Pharmaceutics, 2023 - mdpi.com
Despite the recent advances in this field, there are limited methods for translating organoid-
based study results to clinical response. The goal of this study was to develop a …
based study results to clinical response. The goal of this study was to develop a …
N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination
C Shen, J Liu, F Xie, Y Yu, X Ma, D Hu, C Liu, Y Wang - Cancer Letters, 2024 - Elsevier
The mechanism underlying N6-methyladenosine (m6A) modification in bladder cancer (BC)
remains elusive. We identified that the RBM15/METTL3 complex enhances m6A …
remains elusive. We identified that the RBM15/METTL3 complex enhances m6A …
Hyaluronic acid-conjugated methotrexate and 5-fluorouracil for targeted drug delivery
W Shao, Y Yang, W Shen, L Ren, P Zhu - International Journal of …, 2024 - Elsevier
The delivery of chemotherapeutical drugs via nanomaterials has become a focus of
pharmaceutical research over several decades due to improved drug delivery to cancer …
pharmaceutical research over several decades due to improved drug delivery to cancer …
Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing
H Lin, H Fu, S Sun, H Yin, J Yuan, J Liao - Heliyon, 2024 - cell.com
Objectives FGFR4-variant and wild-type colorectal cancer (CRC) organoids were developed
to investigate the effects of FGFR4-targeted drugs, including FGFR4-IN and erdafitinib, on …
to investigate the effects of FGFR4-targeted drugs, including FGFR4-IN and erdafitinib, on …
Patient-derived Organoid Model for Predicting the Chemoresponse in Patients With Colorectal Cancer
K Yi, SH Park, DU Kim, J DA YE, HJ Lee, G Am Song… - in vivo, 2023 - iv.iiarjournals.org
Background/Aim: Cancer mortality has decreased due to the contribution of extensive
research on cancer treatment, including chemotherapy, radiation, and immunotherapy …
research on cancer treatment, including chemotherapy, radiation, and immunotherapy …
Manejo de técnicas de biopsia líquida, generación de organoides y estudio de nuevas terapias en cáncer colorrectal
N Ferreira Orero - 2024 - riunet.upv.es
[ES] El cáncer colorrectal (CCR) representa una carga significativa para la salud pública,
siendo la segunda causa principal de muertes por cancer a nivel global, de acuerdo con la …
siendo la segunda causa principal de muertes por cancer a nivel global, de acuerdo con la …