Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Advancement of scaffold-based 3D cellular models in cancer tissue engineering: an update

K Unnikrishnan, LV Thomas, RM Ram Kumar - Frontiers in oncology, 2021 - frontiersin.org
The lack of traditional cancer treatments has resulted in an increased need for new clinical
techniques. Standard two-dimensional (2D) models used to validate drug efficacy and …

Trends in photopolymerizable bioinks for 3D bioprinting of tumor models

SB Gugulothu, S Asthana, S Homer-Vanniasinkam… - JACS Au, 2023 - ACS Publications
Three-dimensional (3D) bioprinting technologies involving photopolymerizable bioinks
(PBs) have attracted enormous attention in recent times owing to their ability to recreate …

[HTML][HTML] The biomimetic extracellular matrix: a therapeutic tool for breast cancer research

M Tamayo-Angorrilla, JL de Andrés, G Jiménez… - Translational …, 2022 - Elsevier
Background: A deeper knowledge of the functional versatility and dynamic nature of the
ECM has improved the understanding of cancer biology. Translational Significance: This …

Decellularized colorectal cancer matrices as bioactive scaffolds for studying tumor-stroma interactions

 Marques-Magalhães, T Cruz, ÂM Costa, D Estêvão… - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer is an increasingly prevalent disease that accounts for
substantial mortality and morbidity and is responsible for an impaired quality of life. This …

Polysaccharides and structural proteins as components in three-dimensional scaffolds for breast cancer tissue models: A review

E Pasquier, J Rosendahl, A Solberg, A Ståhlberg… - Bioengineering, 2023 - mdpi.com
Breast cancer is the most common cancer among women, and even though treatments are
available, efficiency varies with the patients. In vitro 2D models are commonly used to …

The study of the extracellular matrix in chronic inflammation: a way to prevent cancer initiation?

A Marangio, A Biccari, E D'Angelo, F Sensi… - Cancers, 2022 - mdpi.com
Simple Summary The extracellular matrix (ECM) is a key orchestrator in several diseases'
initiation and progression. Alterations in its components and the remodeling process …

Patient‐Derived Microphysiological Systems for Precision Medicine

J Ko, J Song, N Choi, HN Kim - Advanced Healthcare Materials, 2024 - Wiley Online Library
Patient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in
precision medicine that provide valuable insight into individual patient characteristics. This …

Matrix mechanophysical factor: pore size governs the cell behavior in cancer

M Saif Ur Rahman, J Wu, H Chen, C Sun… - … in Physics: X, 2023 - Taylor & Francis
Cancer tissues are a heterogeneously multifaceted assembly. Understanding the
relationship of tumors with their microenvironment is also required to understand the tumor …

5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical information

S Salerno, A Ståhlberg, A Holdfeldt… - Journal of Translational …, 2022 - Springer
Background Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately,
many patients do not respond to standard chemotherapy treatments and develop disease …