The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …

The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular
turnover. There is growing evidence that the ageing of the immune system is initiated at the …

Discovering the biological basis of aging is one of the greatest remaining challenges for
science. Work on the biology of aging has discovered a range of interventions and pathways …

The discovery of biomarkers able to predict biological age of individuals is a crucial goal in
aging research. Recently, researchers' attention has turn toward epigenetic markers of …

The idea that resources are limited and animals can maximise fitness by trading costly
activities off against one another forms the basis of life-history theory. Although investment in …

Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …

Age is a fundamental aspect of animal ecology, but is difficult to determine in many species.
Humpback whales exemplify this as they have a lifespan comparable to humans, mature …

Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and
an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem …