Hydrogels are fascinating biomaterials that can act as a support for cells, ie, a scaffold, in
which they can organize themselves spatially in a similar way to what occurs in vivo …

Patient‐derived organoids (PDOs) developed ex vivo and in vitro are increasingly used for
therapeutic screening. They provide a more physiologically relevant model for drug …

High-fidelity in vitro tumor models are important for preclinical drug discovery processes.
Currently, the most commonly used model for in vitro drug testing remains the two …

Recent advances in single-cell and multicellular microfluidics technology have provided
powerful tools for studying cancer biology and immunology. The ability to create controlled …

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are
biocompatible and can influence cellular metabolism, making them attractive bioengineering …

Abstract Three-dimensional (3D) cell culture models have been extensively utilized in
various mechanistic studies as well as for drug development studies as superior in vitro …

3D cell culture can mimic tumor pathophysiology, which reflects cellular morphology and
heterogeneity, strongly influencing gene expression, cell behavior, and intracellular …

A low-cost, robust, and flexible device for generating an array of miniaturized 3D spheroid
tumor models was designed and developed. The device consisting of two layers: a layer …

Vascular system is involved in various essential life activities, including both normal
embryonic organ development and pathological processes, such as tumorigenesis. In …

A number of cellular organisms, such as yeast, bacteria and slime moulds, exhibit dynamic
behaviour, in particular switching and rhythms that are controlled by feedback mechanisms …