Mitochondrial dysfunction and therapeutic perspectives in cardiovascular diseases

Y Liu, Y Huang, C Xu, P An, Y Luo, L Jiao… - International journal of …, 2022 - mdpi.com
High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide
attention. It has been reported that mitochondrial dysfunction is one of the most important …

Mitochondrial dysfunction in cardiovascular diseases: potential targets for treatment

J Yang, Q Guo, X Feng, Y Liu, Y Zhou - Frontiers in cell and …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

The role of mitochondrial dysfunction in vascular disease, tumorigenesis, and diabetes

OA Zhunina, NG Yabbarov, AV Grechko… - Frontiers in Molecular …, 2021 - frontiersin.org
Mitochondrial dysfunction is known to be associated with a wide range of human
pathologies, such as cancer, metabolic, and cardiovascular diseases. One of the possible …

The therapeutic strategies targeting mitochondrial metabolism in cardiovascular disease

X Huang, Z Zeng, S Li, Y Xie, X Tong - Pharmaceutics, 2022 - mdpi.com
Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

The role of mitochondria in cardiovascular diseases

AV Poznyak, EA Ivanova, IA Sobenin, SF Yet… - Biology, 2020 - mdpi.com
The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a
central player in the regulation of cellular metabolism and a powerful controller of cellular …

[HTML][HTML] Mitochondria and cardiovascular diseases—from pathophysiology to treatment

G Siasos, V Tsigkou, M Kosmopoulos… - Annals of …, 2018 - ncbi.nlm.nih.gov
Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

Mitochondrial dysfunction and heart disease: critical appraisal of an overlooked association

G Bisaccia, F Ricci, S Gallina, A Di Baldassarre… - International Journal of …, 2021 - mdpi.com
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …

Mitochondrial DNA Is a Vital Driving Force in Ischemia‐Reperfusion Injury in Cardiovascular Diseases

H Liu, X Liu, J Zhou, T Li - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
According to the latest Global Burden of Disease Study, cardiovascular disease (CVD) is the
leading cause of death, and ischemic heart disease and stroke are the cause of death in …