The role of the TGF‐β coreceptor endoglin in cancer

E Pérez-Gómez, G Del Castillo… - The Scientific World …, 2010 - Wiley Online Library
Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta
(TGF‐β) that interacts with type I and type II TGF‐β receptors and modulates TGF‐β …

Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy

F Nassiri, MD Cusimano, BW Scheithauer… - Anticancer …, 2011 - ar.iiarjournals.org
Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis

C Ollauri-Ibáñez, E Núñez-Gómez, C Egido-Turrión… - Angiogenesis, 2020 - Springer
Endoglin (CD105) is an auxiliary receptor for members of the TFG-β superfamily. Whereas it
has been demonstrated that the deficiency of endoglin leads to minor and defective …

Elevated expression of endoglin, a component of the TGF‐β‐receptor complex, correlates with proliferation of tumor endothelial cells

DW Miller, W Graulich, B Karges, S Stahl… - … journal of cancer, 1999 - Wiley Online Library
Endoglin/CD105 is a membrane protein involved in the TGF‐β receptor signalling pathway.
Endoglin expression has been reported to be selective for a few cell types, in particular …

Endoglin (CD105): a target for anti-angiogenetic cancer therapy

E Fonsatti, M Altomonte, P Arslan… - Current drug targets, 2003 - ingentaconnect.com
Targeting of tumor vasculature is a promising strategy for cancer treatment. Among
endothelial cell markers, Endoglin, a cell membrane glycoprotein, is emerging as an …

Endoglin targeting: lessons learned and questions that remain

Y Liu, M Paauwe, AB Nixon… - International journal of …, 2020 - mdpi.com
Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β
coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its …

Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome

LA Henry, DA Johnson, D Sarrió, S Lee, PR Quinlan… - Oncogene, 2011 - nature.com
Tumor growth factor-β (TGF-β) signaling in cancer has been implicated in growth
suppression of early lesions and enhancing tumor cell invasion and metastasis. However …

Endoglin: beyond the endothelium

MJA Schoonderwoerd, MJTH Goumans… - Biomolecules, 2020 - mdpi.com
Endoglin, a type-III accessory receptor for the Transforming Growth Factor (TGF)-β
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …

Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies

E Fonsatti, L Sigalotti, P Arslan… - Current Cancer Drug …, 2003 - ingentaconnect.com
Angiogenesis is crucial for tumor development and progression, and antiangiogenetic
therapy represents a promising approach for cancer treatment. Thus, the in-depth …

Endoglin: an accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

E Fonsatti, LD Vecchio, M Altomonte… - Journal of cellular …, 2001 - Wiley Online Library
Endoglin (CD105) is a cell membrane glycoprotein over‐expressed on highly proliferating
endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within …