Assessing the effect of interaction between lifestyle and longitudinal changes in brain structure on sleep phenotypes

Y Zhao, X Yang, S Cheng, C Li, D He, Q Cai… - Cerebral …, 2023 - academic.oup.com
Longitudinal changes in brain structure and lifestyle can affect sleep phenotypes. However,
the influence of the interaction between longitudinal changes in brain structure and lifestyle …

The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

Y Li, BJ Sahakian, J Kang, C Langley, W Zhang, C Xie… - Nature Aging, 2022 - nature.com
Sleep duration, psychiatric disorders and dementias are closely interconnected in older
adults. However, the underlying genetic mechanisms and brain structural changes are …

Sleep duration and brain structure–phenotypic associations and genotypic covariance

AM Fjell, Ø Sørensen, Y Wang, IK Amlien, WFC Baaré… - bioRxiv, 2022 - biorxiv.org
The question of how much sleep is best for the brain attracts scientific and public interest,
and there is concern that insuficient sleep leads to poorer brain health. However, it is …

Sleep disorders causally affect the brain cortical structure: A Mendelian randomization study

X Gao, T Wei, S Xu, W Sun, B Zhang, C Li, R Sui, N Fei… - Sleep Medicine, 2023 - Elsevier
Background s: Previous studies have reported that patients with sleep disorders have
altered brain cortical structures. However, the causality has not been determined. We …

8. A CROSS-POPULATION GENOME-WIDE ASSOCIATION STUDY OF SLEEP DURATION

I Austin-Zimmerman, D Levey, J Deak… - European …, 2023 - Elsevier
Background Adequate sleep duration is essential for regulating physiological and cognitive
functions. Disturbed sleep has been linked to a wide range of comorbidities, including …

Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study

Q Wang, S Hu, L Qi, X Wang, G Jin, D Wu… - Behavioral and Brain …, 2023 - Springer
Background Emerging evidence suggests bidirectional causal relationships between sleep
disturbance and psychiatric disorders, but the underlying mechanisms remain unclear …

Sleep polygenic risk score is associated with cognitive changes over time

A Tsapanou, N Mourtzi, S Charisis, A Hatzimanolis… - Genes, 2021 - mdpi.com
Sleep problems have been associated with cognition, both cross-sectionally and
longitudinally. Specific genes have been also associated with both sleep regulation and …

The genetic liability for insomnia is associated with lower amount of slow wave sleep in young and healthy individuals

P Ghaemmaghami, V Muto, M Jaspar… - … Abstract: Belgian Brain …, 2018 - frontiersin.org
Introduction. Identifying risk factors for insomnia in individuals that are likely to develop
insomnia is needed to develop prevention strategies. Novel genetic tools using results of …

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

LM García-Marín, AI Campos, NG Martin… - Sleep, 2021 - academic.oup.com
Abstract Study Objective Sleep is essential for both physical and mental health, and there is
a growing interest in understanding how different factors shape individual variation in sleep …

Dissecting the genetic and causal relationship between sleep-related traits and common brain disorders

B Xue, X Jian, L Peng, C Wu, A Fahira, AAS Syed… - Sleep Medicine, 2024 - Elsevier
Background There is a profound connection between abnormal sleep patterns and brain
disorders, suggesting a shared influential association. However, the shared genetic basis …