Landscape of preterm birth therapeutics and a path forward

BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

BM Arman, NK Binder, N de Alwis… - …, 2023 - rep.bioscientifica.com
In brief Preterm birth is the leading cause of perinatal morbidity and mortality; however,
current therapies offer limited efficacy to delay birth and improve neonatal outcomes. This …

Tocolytics for delaying preterm birth: a network meta‐analysis (0924)

A Wilson, VA Hodgetts-Morton… - Cochrane Database …, 2022 - cochranelibrary.com
Background Preterm birth is the leading cause of death in newborns and children. Tocolytic
drugs aim to delay preterm birth by suppressing uterine contractions to allow time for …

Recent advances in the therapeutic management of preterm labour

RJ Sawdy, PR Bennett - Current Opinion in Obstetrics and …, 1999 - journals.lww.com
Preterm labour and delivery pose an increasing problem to the obstetrician. Improvements
in tocolysis with the recent introduction of new therapeutic targeting strategies, and a …

Cost-effectiveness of antenatal corticosteroids and tocolytic agents in the management of preterm birth: A systematic review

E Sebastian, C Bykersma, A Eggleston, KE Eddy… - …, 2022 - thelancet.com
Background Preterm birth is a leading cause of neonatal mortality and morbidity, and
imposes high health and societal costs. Antenatal corticosteroids (ACS) to accelerate fetal …

Emerging tocolytics: challenges in designing and testing drugs to delay preterm delivery and prolong pregnancy

DM Olson, I Christiaens, S Gracie… - Expert opinion on …, 2008 - Taylor & Francis
The global rate of preterm delivery (before 37 completed weeks of pregnancy) is increasing
and there are no effective means available to prevent this rise. Prematurity is the principal …

Tocolytic therapy for preterm delivery: systematic review and network meta-analysis

DM Haas, DM Caldwell, P Kirkpatrick, JJ McIntosh… - Bmj, 2012 - bmj.com
Objective To determine the most effective tocolytic agent at delaying delivery. Design
Systematic review and network meta-analysis. Data sources Cochrane Central Register of …

Combination of tocolytic agents for inhibiting preterm labour

JP Vogel, JM Nardin, T Dowswell… - Cochrane database …, 2014 - cochranelibrary.com
Background Preterm birth represents the single largest cause of mortality and morbidity for
newborns and a major cause of morbidity for pregnant women. Tocolytic agents include a …

Tocolysis for acute preterm labor: where have we been, where are we now, and where are we going?

R Navathe, V Berghella - American journal of perinatology, 2016 - thieme-connect.com
Tocolytics have been used for over 60 years for women with preterm labor, which ultimately
can lead to preterm birth (PTB). Diagnosing preterm labor is challenging, but use of …

Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative …

RI Zahroh, A Hazfiarini, KE Eddy, JP Vogel… - PLoS …, 2022 - journals.plos.org
Background Preterm birth-related complications are the leading cause of death in newborns
and children under 5. Health outcomes of preterm newborns can be improved with …