Lung macrophages mature after birth, placing newborn infants, particularly those born
preterm, within a unique window of susceptibility to disease. We hypothesized that in …

In preterm infants, exposure to inflammation increases the risk of bronchopulmonary
dysplasia, a chronic, developmental lung disease. Although macrophages are the key cells …

Background The etiology of persistent lung inflammation in preterm infants with chronic lung
disease of prematurity (CLD) is poorly characterized, hampering efforts to stratify prognosis …

Introduction Inflammation is a key driver of morbidity in the vulnerable preterm infant
exposed to pre-and postnatal hazards and significantly contributes to chronic lung disease …

Bronchopulmonary dysplasia is a common pulmonary complication of extreme prematurity.
Arrested lung development leads to bronchopulmonary dysplasia, but the molecular …

Background Macrophages are traditionally associated with inflammation and host defence,
however a greater understanding of macrophage heterogeneity is revealing their essential …

In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into
the development of injury and ultimately chronic disease, also known as bronchopulmonary …

Bronchopulmonary dysplasia (BPD) remains a devastating consequence of prematurity.
Repeated inflammatory insults worsen lung injury, but there are no predictors for BPD …

Bronchopulmonary dysplasia (BPD) is the most common, serious sequela of premature
birth. Inflammation is a major contributor to the pathogenesis of BPD. Often initiated by a …

Preterm infants are highly susceptible to sustained lung inflammation, which may be
triggered by exposure to multiple environmental cues such as supplemental oxygen (O2) …