[PDF][PDF] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …
few studies have thoroughly investigated their best practices in global populations across …
Improving reporting standards for polygenic scores in risk prediction studies
H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
[PDF][PDF] Incorporating family history of disease improves polygenic risk scores in diverse populations
Polygenic risk scores (PRSs) derived from genotype data and family history (FH) of disease
provide valuable information for predicting disease risk, but PRSs perform poorly when …
provide valuable information for predicting disease risk, but PRSs perform poorly when …
[HTML][HTML] Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies
Genetic risk prediction is an important problem in human genetics, and accurate prediction
can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has …
can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has …
XPXP: improving polygenic prediction by cross-population and cross-phenotype analysis
Motivation As increasing sample sizes from genome-wide association studies (GWASs),
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …
Tutorial: a guide to performing polygenic risk score analyses
SW Choi, TSH Mak, PF O'Reilly - Nature protocols, 2020 - nature.com
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …
genetic liability to a trait or disease, calculated according to their genotype profile and …
[HTML][HTML] Polygenic risk scores: from research tools to clinical instruments
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …
disorders have a polygenic genetic architecture and have enabled researchers to identify …
[HTML][HTML] Perspective: the clinical use of polygenic risk scores: race, ethnicity, and health disparities
Polygenic risk scores (PRS) are an emerging precision medicine tool based on multiple
gene variants that, taken alone, have weak associations with disease risks, but collectively …
gene variants that, taken alone, have weak associations with disease risks, but collectively …
[HTML][HTML] Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
Background Polygenic risk scores (PRS) are valuable to translate the results of genome-
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …
[HTML][HTML] Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists
A polygenic risk score estimates the genetic risk of an individual for some disease or trait,
calculated by aggregating the effect of many common variants associated with the condition …
calculated by aggregating the effect of many common variants associated with the condition …