Advanced in vitro kidney models are of great importance to the study of renal physiology and
disease. Kidney tubuloids can be established from primary cells derived from adult kidney …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

The renal proximal tubule epithelium is responsible for active secretion of endogenous and
exogenous waste products from the body and simultaneous reabsorption of vital compounds …

Traditional approaches to pathophysiology are advancing but still have many limitations that
arise from real biologic systems and their associated physiological phenomena being too …

Scalable fabrication concepts of 3D kidney tissue models are required to enable their
application in pharmaceutical high-throughput screenings. Yet the reconstruction of complex …

Engineered human kidney‐on‐a‐chip platforms show tremendous promise for disease
modeling and drug screening. Outstanding challenges exist, however, in reconstructing the …

Renal disease is a global problem with unsustainable health-care costs. There currently
exists a lack of accurate human renal disease models that take into account the complex …

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

Progress in understanding kidney disease mechanisms and the development of targeted
therapeutics have been limited by the lack of functional in vitro models that can closely …

In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem
or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models …