Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of
interleukin 1β (IL-1β) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis …

The inflammatory nature of atherosclerosis is well established but the agent (s) that incite
inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible …

In atherosclerosis and Alzheimer's disease, deposition of the altered self components
oxidized low-density lipoprotein (LDL) and amyloid-β triggers a protracted sterile …

Background Chronic inflammation of the arterial wall is a key element in the pathogenesis of
atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive …

NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of
diseases. Identification of endogenous inflammasome activators is essential for the …

Cytosolic pathogen-and damage-associated molecular patterns are sensed by pattern
recognition receptors, including members of the nucleotide-binding domain and leucine-rich …

Inflammation is a protective attempt by the host to remove injurious stimuli and initiate the
tissue healing process. The inflammatory response must be actively terminated, however …

The emergence of chronic inflammation during obesity in the absence of overt infection or
well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor …

Intracellular sensing of stress and danger signals initiates inflammatory innate immune
responses by triggering inflammasome assembly, caspase-1 activation and pyroptotic cell …

Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β
peptide drives cerebral neuroinflammation by activating microglia,. Indeed, amyloid-β …