Highlights•We summarize and update the germinal center model of Epstein–Barr virus
persistence.•We discuss the weaknesses and strengths of alternate models.•The role of …

In this paper we demonstrate that during acute infection with Epstein-Barr virus (EBV), the
peripheral blood fills up with latently infected, resting memory B cells to the point where up to …

The current model of Epstein-Barr virus (EBV) infection and persistence in vivo proposes
that EBV uses the germinal center (the GC model) to establish a quiescent latent infection in …

Persistent infection by EBV is explained by the germinal center model (GCM) which provides
a satisfying and currently the only explanation for EBVs disparate biology. Since the GCM …

Abstract In vitro, Epstein-Barr virus (EBV) will infect any resting B cell, driving it out of the
resting state to become an activated proliferating lymphoblast. Paradoxically, EBV persists in …

Epstein-Barr virus infects human B lymphocytes. The interaction between the virus and
these cells has been the subject of investigation for over three decades. Recent in vitro and …

Most adult humans are infected benignly and for life with the herpesvirus Epstein-Barr virus.
EBV has been a focus of research because of its status as a candidate tumor virus for a …

Epstein-Barr virus infection has been epidemiologically associated with the development of
multiple autoimmune diseases, particularly systemic lupus erythematosus and multiple …

Epstein-Barr virus (EBV) infection transforms B cells in vitro and is associated with human B
cell lymphomas. The major EBV oncoprotein, latent membrane protein 1 (LMP1), mimics …

When Epstein-Barr virus (EBV) infects B cells in vitro, the result is a proliferating lymphoblast
that expresses at least nine latent proteins. It is generally believed that these cells are …