Patient‐derived cancer models that reconstitute the characteristics of the tumor
microenvironment may facilitate efforts in precision immune‐oncology and the discovery of …

Identification of novel drug targets is a critical step in drug development. Many recent studies
have produced multiple types of data, which provides an opportunity to mine the …

Background Pancreatic ductal adenocarcinoma has the lowest survival rate among all major
cancers and is the third leading cause of cancer-related mortality. The stagnant survival …

There is a clear and unmet clinical need for biomarkers to predict responsiveness to
chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor …

Digestive system cancers account for nearly half of all cancers around the world and have a
high mortality rate. Cell culture and animal models represent cornerstones of digestive …

The in vitro organoid model is a major technological breakthrough that has been established
as an important tool in many basic biological and clinical applications. This near …

Organoids are a new type of 3D model for tumor research, which makes up for the
shortcomings of cell lines and xenograft models, and promotes the development of …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Patient‐
derived organoid (PDO) has great potential in precision oncology, but low success rate, time …

For many years, cell lines and animal models have been essential to improve our
understanding of the basis of cell metabolism, signaling, and genetics. They also provided …

The drug 5-fluorouracil (5-Fu) is the critical composition of colorectal cancer (CRC)
treatments. Prognostic and predictive molecular biomarkers for CRC patients (CRCpts) …