On the chemical and biological characteristics of multifunctional compounds for the treatment of Parkinson's disease

O García-Beltrán, PJ Urrutia, MT Núñez - Antioxidants, 2023 - mdpi.com
Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative
damage and inflammation are pathognomonic features of Parkinson's disease (PD) and …

A review on natural antioxidants for their role in the treatment of Parkinson's disease

P Mittal, S Dhankhar, S Chauhan, N Garg… - Pharmaceuticals, 2023 - mdpi.com
The neurodegenerative condition known as Parkinson's disease (PD) is brought on by the
depletion of dopaminergic neurons in the basal ganglia, which is the brain region that …

Iron chelators as potential therapeutic agents for Parkinson's disease

CA Perez, Y Tong, M Guo - Current bioactive compounds, 2008 - ingentaconnect.com
Parkinson's disease (PD) is a neurological disorder characterized by the progressive
impairment of motor skills in patients. Growing evidence suggests that abnormal redox …

Evidence for oxidative pathways in the pathogenesis of PD: are antioxidants candidate drugs to ameliorate disease progression?

A Leathem, T Ortiz-Cerda, JM Dennis… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a
complex and variable interplay between elements including age, genetic, and …

Chelators in the treatment of iron accumulation in Parkinson′ s disease

RB Mounsey, P Teismann - International journal of cell biology, 2012 - Wiley Online Library
Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have
been found in the brains of patients of numerous neurodegenerative disorders, including …

Natural products combating neurodegeneration: Parkinson's disease

M Solayman, MA Islam, F Alam, I Khalil… - Current Drug …, 2017 - ingentaconnect.com
Parkinson's disease (PD) is characterized by neurodegeneration and a progressive
functional impairment of the midbrain nigral dopaminergic neurons. The cause remains …

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

O Weinreb, S Mandel, MBH Youdim, T Amit - Free Radical Biology and …, 2013 - Elsevier
Brain iron accumulation has been implicated in a host of chronic neurological diseases,
including Parkinson's disease (PD). The elevated iron levels observed in the substantia …

The potential role of iron chelators in the treatment of Parkinson's disease and related neurological disorders

M Gassen, MBH Youdim - Pharmacology & toxicology, 1997 - Wiley Online Library
Neurodegeneration is characterized by a marked accumulation of iron in the affected brain
regions. The reason for this is still unknown. In this article we review the available data on …

Prevention of progression in Parkinson's disease

J Aaseth, P Dusek, PM Roos - Biometals, 2018 - Springer
Environmental influences affecting genetically susceptible individuals seem to contribute
significantly to the development of Parkinson's disease (PD). Xenobiotic exposure including …

Advances in Parkinson's disease drugs

A Di Stefano, L Marinelli - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative age-related
disorder worldwide after Alzheimer's disease [1–3], in which environmental and genetic …