The neurodegenerative condition known as Parkinson's disease (PD) is brought on by the depletion of dopaminergic neurons in the basal ganglia, which is the brain region that …
CA Perez, Y Tong, M Guo - Current bioactive compounds, 2008 - ingentaconnect.com
Parkinson's disease (PD) is a neurological disorder characterized by the progressive impairment of motor skills in patients. Growing evidence suggests that abnormal redox …
A Leathem, T Ortiz-Cerda, JM Dennis… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay between elements including age, genetic, and …
RB Mounsey, P Teismann - International journal of cell biology, 2012 - Wiley Online Library
Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have been found in the brains of patients of numerous neurodegenerative disorders, including …
Parkinson's disease (PD) is characterized by neurodegeneration and a progressive functional impairment of the midbrain nigral dopaminergic neurons. The cause remains …
O Weinreb, S Mandel, MBH Youdim, T Amit - Free Radical Biology and …, 2013 - Elsevier
Brain iron accumulation has been implicated in a host of chronic neurological diseases, including Parkinson's disease (PD). The elevated iron levels observed in the substantia …
Neurodegeneration is characterized by a marked accumulation of iron in the affected brain regions. The reason for this is still unknown. In this article we review the available data on …
Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson's disease (PD). Xenobiotic exposure including …
A Di Stefano, L Marinelli - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative age-related disorder worldwide after Alzheimer's disease [1–3], in which environmental and genetic …