Dynamic bioinspired coculture model for probing ER+ breast cancer dormancy in the bone marrow niche
Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells
(DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor …
(DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor …
Mesenchymal stem cell–secreted extracellular vesicles instruct stepwise dedifferentiation of breast cancer cells into dormancy at the bone marrow perivascular region
OA Sandiford, RJ Donnelly, MH El-Far, LM Burgmeyer… - Cancer research, 2021 - AACR
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as
cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs …
cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs …
Molecular interplay between dormant bone marrow-resident cells (BMRCs) and CTCs in breast cancer
D Boral, HN Liu, SR Kenney, D Marchetti - Cancers, 2020 - mdpi.com
Despite widespread knowledge that bone marrow-resident breast cancer cells (BMRCs)
affect tumor progression, signaling mechanisms of BMRCs implicated in maintaining long …
affect tumor progression, signaling mechanisms of BMRCs implicated in maintaining long …
Understanding ER+ breast cancer dormancy using bioinspired synthetic matrices for long‐term 3D culture and insights into late recurrence
Late recurrences of breast cancer are hypothesized to originate from disseminated tumor
cells that re‐activate after a long period of dormancy,≥ 5 years for estrogen‐receptor …
cells that re‐activate after a long period of dormancy,≥ 5 years for estrogen‐receptor …
Disseminated breast cancer cells acquire a highly malignant and aggressive metastatic phenotype during metastatic latency in the bone
CG Marsden, MJ Wright, L Carrier, K Moroz… - PLoS …, 2012 - journals.plos.org
Background Disseminated tumor cells (DTCs) in the bone marrow may exist in a dormant
state for extended periods of time, maintaining the ability to proliferate upon activation …
state for extended periods of time, maintaining the ability to proliferate upon activation …
Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow
JM Buschhaus, BA Humphries, SS Eckley, TH Robison… - Oncogene, 2020 - nature.com
Abstract Estrogen receptor-positive (ER+) breast cancer can recur up to 20 years after initial
diagnosis. Delayed recurrences arise from disseminated tumors cells (DTCs) in sites such …
diagnosis. Delayed recurrences arise from disseminated tumors cells (DTCs) in sites such …
The bone marrow niche in support of breast cancer dormancy
Despite the success in detecting breast cancer (BC) early and, with aggressive therapeutic
intervention, BC remains a clinical problem. The bone marrow (BM) is a favorable metastatic …
intervention, BC remains a clinical problem. The bone marrow (BM) is a favorable metastatic …
Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone
Breast cancer metastatic relapse can occur years after therapy, indicating that disseminated
breast cancer cells (BCCs) have a prolonged dormant phase before becoming proliferative …
breast cancer cells (BCCs) have a prolonged dormant phase before becoming proliferative …
Awakening of Dormant Breast Cancer Cells in the Bone Marrow
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer cells travel via the bloodstream to the bone before the
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …
A novel model of dormancy for bone metastatic breast cancer cells
Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the
disease. Although dissemination is an early event in breast cancer, extended periods of …
disease. Although dissemination is an early event in breast cancer, extended periods of …