Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC)
patients. How to improve therapeutic options for patients with metastatic CRC is the core …

Colorectal cancer (CRC) is among the top 3 leading causes of cancer-related deaths, and
tumor malignant progression and metastases contribute to the high mortality of advanced …

In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC)
and well-matched liver metastatic CRC using single-cell and spatial transcriptome RNA …

The tumor microenvironment (TME) is connected to immunotherapy responses, but it
remains unclear how cancer cells and host tissues differentially influence the immune …

Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its
microenvironment is modified to provide a niche that is conducive for colorectal cancer cell …

Patients with colorectal liver metastasis (CLM) present with heterogenous clinical outcomes
and improved classification is needed to ameliorate the therapeutic output. Macrophages …

The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …

The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell
populations, and its composition is related to cancer prognosis and response to clinical …