Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …
health disparities. We propose PolyPred, a method that improves cross-population …
Leveraging fine-mapping and non-European training data to improve cross-population polygenic risk scores
Polygenic risk scores (PRS) based on European training data suffer reduced accuracy in
non-European target populations, exacerbating health disparities. This loss of accuracy …
non-European target populations, exacerbating health disparities. This loss of accuracy …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
[PDF][PDF] A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …
European population into different risk groups. However, PRSs are less accurate in non …
[HTML][HTML] Polygenic prediction via Bayesian regression and continuous shrinkage priors
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior …
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior …
[HTML][HTML] Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic scores (PGS) have been widely used to predict disease risk using variants
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
[PDF][PDF] Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
TB Cavazos, JS Witte - Human Genetics and Genomics Advances, 2021 - cell.com
The majority of polygenic risk scores (PRSs) have been developed and optimized in
individuals of European ancestry and may have limited generalizability across other …
individuals of European ancestry and may have limited generalizability across other …
[HTML][HTML] Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
Background Polygenic risk scores (PRS) are valuable to translate the results of genome-
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …