The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …

The Wnt signaling pathway is a highly conserved system that regulates complex biological
processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to …

The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell
communication in diverse developmental processes. The loss or inappropriate activation of …

The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling
during development of animals. Recent biochemical and genetic analyses have led to …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Wnt-mediated signal transduction pathways have long been recognized for their roles in
regulating embryonic development, and have more recently been linked to cancer …

The Wnt proteins constitute a family of secreted glycoproteins the members of which have
essential signaling roles during embryogenesis. The recent identification of several new …