People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities,
particularly cardiovascular disease and cancer, than people without HIV,,,–. In view of …

People living with human immunodeficiency virus (PLWH) have significantly increased risk
for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal …

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the
development of hematological malignancies (HM) and cardiovascular diseases. Previous …

Several genetic alterations characteristic of leukemia and lymphoma have been detected in
the blood of individuals without apparent hematological malignancies. The Cancer Genome …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown. The age-related acquisition of …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

HIV causes a chronic infection characterized by depletion of CD4+ T lymphocytes and the
development of opportunistic infections. Despite drugs that inhibit viral spread, HIV infection …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …