Organelles perform critical biological functions due to their distinct molecular composition
and internal environment. Disorders in organelles or their interacting networks have been …

Fluorescence microscopy imaging has become one of the most useful techniques to assess
the activity of individual cells, subcellular trafficking of signals to and between organelles …

Traditional screening paradigms often focus on single targets. To facilitate drug discovery in
the more complex physiological environment of a cell or organism, powerful cellular imaging …

Cellular processes depend on the fidelity of intracellular membrane traffic. Lipids, proteins,
receptor ligands and solute molecules are trafficked to distinct compartments within the cell …

Targeting of drug delivery systems (DDSs) to specific intracellular organelles (ie, subcellular
targeting) has been investigated in numerous publications, but targeting efficiency of these …

The ability of a pharmacologically active molecule selectively to find its target is closely
linked with its potential as a successful therapeutic drug. It has become increasingly evident …

Recent advances in fluorescence imaging techniques and super-resolution microscopy
have extended the applications of fluorescent probes in studying various cellular processes …

Fluorescent tools have emerged as an important tool for studying the distinct chemical
microenvironments of organelles, due to their high specificity and ability to be used in non …

Drug discovery and drug delivery are two main aspects for treatment of a variety of
disorders. However, the real bottleneck associated with systemic drug administration is the …

The ratio between the dose of drug required for optimal efficacy and the dose that causes
toxicity is referred to as the therapeutic window. This ratio can be increased by directing the …