Although the microfabrication techniques for microwells enabled to guide physiologically
relevant three-dimensional cell spheroid formation, there have been substantial interests to …

Despite the potential of a nanofibrous (NF) microwell array as a permeable microwell array
to improve the viability and functions of spheroids, thanks to the superior permeability to both …

Providing control over the geometric shape of cell-laden hydrogel microspheroids, such as
diameter and axial ratio, is critical for their use in biomedical applications. Building on our …

Spheroid cell culture is very useful for further understanding cellular behavior including
motility and biochemical reaction since it mimics three-dimensional (3D) in vivo organ tissue …

The engineered three-dimensional (3D) cell cultivation system for the production of
multicellular spheroids has attracted considerable attention due to its improved in vivo …

Spheroid cultures have been often used to simulate and understand in situ biological
occurrences with potential to be further applied to therapeutic approaches, such as cell …

At present, there is an increasing need to mimic the in vivo micro-environment in the culture
of cells and tissues in micro-tissue engineering. Concave microwells are becoming …

The integration of microfabrication and biomaterials enables construction of miniaturized 3D
microenvironments with biomimetic micro-architectural and functional features to advance …

Multicellular spheroids (MCS), formed by self-assembly of single cells, are commonly used
as a three-dimensional cell culture model to bridge the gap between in vitro monolayer …

A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …