Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

C Rocca, T Soda, EM De Francesco, M Fiorillo… - Journal of Translational …, 2023 - Springer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress

JC Bikomeye, JD Terwoord… - American Journal of …, 2022 - journals.physiology.org
Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic
potential and cause long-term cardiovascular complications in cancer survivors. This has …

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

FG Tahrir, D Langford, S Amini… - Journal of cellular …, 2019 - Wiley Online Library
Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Quality matters? The involvement of mitochondrial quality control in cardiovascular disease

KL Lin, SD Chen, KJ Lin, CW Liou… - Frontiers in Cell and …, 2021 - frontiersin.org
Cardiovascular diseases are one of the leading causes of death and global health problems
worldwide. Multiple factors are known to affect the cardiovascular system from lifestyles …

Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours

S Missiroli, M Perrone, I Genovese, P Pinton… - EBioMedicine, 2020 - thelancet.com
Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

Mitochondrial dysfunction in cardiovascular diseases: potential targets for treatment

J Yang, Q Guo, X Feng, Y Liu, Y Zhou - Frontiers in cell and …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

[HTML][HTML] Molecular regulation of mitochondrial dynamics in cardiac disease

J Nan, W Zhu, MS Rahman, M Liu, D Li, S Su… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Mitochondrial homeostasis is critical for keeping functional heart in response to metabolic or
environmental stresses. Mitochondrial fission and fusion (mitochondrial dynamics) play …

[HTML][HTML] Mitochondria and cardiovascular diseases—from pathophysiology to treatment

G Siasos, V Tsigkou, M Kosmopoulos… - Annals of …, 2018 - ncbi.nlm.nih.gov
Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Mitochondrial quality control in health and cardiovascular diseases

AE Atici, TR Crother, M Noval Rivas - Frontiers in Cell and …, 2023 - frontiersin.org
Cardiovascular diseases (CVDs) are one of the primary causes of mortality worldwide. An
optimal mitochondrial function is central to supplying tissues with high energy demand, such …

Mitochondrial determinants of anti-cancer drug-induced cardiotoxicity

C Rocca, EM De Francesco, T Pasqua, MC Granieri… - Biomedicines, 2022 - mdpi.com
Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis,
playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox …