Activation of the tumor suppressor protein p53 is a critical cellular response to various stress
stimuli and to inappropriate activity of growth-promoting proteins, such as Myc, Ras, E2F …

Metazoan species diversification in general and the adaptation of parasites to their life-style
in particular are due, not only to the evolution of different structural or metabolic proteins, but …

DNA in eukaryotic nucleus is highly condensed with histone proteins as nucleosomes.
Three dimensional arrangements of nucleosomes give rise to the formation of chromatin …

This review will emphasize the concept of anti-inflammation and propose that better
understanding of the resolution phase of the inflammatory response organized by the host …

The immediate-early protein, bICP0, of Bovine herpesvirus 1 (BHV-1) transactivates viral
promoters and stimulates productive infection. bICP0 is expressed constitutively during …

Abstract A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a
mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed …

Histone deacetylase inhibitors (HDIs) induce cell cycle arrest, differentiation and/or
apoptosis in numerous cancer cell types and have shown promise in clinical trials. These …

The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300
acetyltransferases function as transcriptional co-activators and play critical roles in cell …

The coiled-coil coactivator (CoCoA) is involved in transcriptional activation of target genes
by nuclear receptors and the xenobiotic aryl hydrocarbon receptor, as well as target genes …

The N-terminal region of adenovirus E1A interacts with histone acetyl transferases (HATs)
such as p300, P/CAF, and GCN5. The C-terminal region interacts with the transcriptional …