Gβ-Like CpcB Plays a Crucial Role for Growth and Development of Aspergillus nidulans and Aspergillus fumigatus

Q Kong, L Wang, Z Liu, NJ Kwon, SC Kim, JH Yu - PLoS One, 2013 - journals.plos.org
Growth, development, virulence and secondary metabolism in fungi are governed by
heterotrimeric G proteins (G proteins). A Gβ-like protein called Gib2 has been shown to …

Molecular Characterization of Gβ-Like Protein CpcB Involved in Antifungal Drug Susceptibility and Virulence in A. fumigatus

Z Cai, Y Chai, C Zhang, R Feng, H Sang… - Frontiers in …, 2016 - frontiersin.org
Aspergillus fumigatus is an airborne human fungal pathogen that can survive in a wide
range of environmental condition. G protein complex transduces external signals from a …

The Gβ-like protein CpcB is required for hyphal growth, conidiophore morphology and pathogenicity in Aspergillus fumigatus

Z Cai, Y Chai, C Zhang, W Qiao, H Sang… - Fungal Genetics and …, 2015 - Elsevier
CpcB (cross pathway control B) encodes a yeast Cpc2 and mammalian RACK1 (receptor for
activated protein kinase C) ortholog, which is a WD repeat protein with functional homology …

Comparative Characterization of G Protein α Subunits in Aspergillus fumigatus

YH Choi, NY Lee, SS Kim, HS Park, KS Shin - Pathogens, 2020 - mdpi.com
Trimeric G proteins play a central role in the G protein signaling in filamentous fungi and Gα
subunits are the major component of trimeric G proteins. In this study, we characterize three …

Heterotrimeric Gα protein Pga1 of Penicillium chrysogenum controls conidiation mainly by a cAMP-independent mechanism

RO García-Rico, F Fierro… - Biochemistry and Cell …, 2008 - cdnsciencepub.com
Fungal heterotrimeric G proteins regulate different processes related to development, such
as colony growth and asexual sporulation, the main mechanism of propagation in …

Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans

Y Wang, G Shen, J Gong, D Shen, A Whittington… - Journal of Biological …, 2014 - ASBMB
Gβ-like/RACK1 functions as a key mediator of various pathways and contributes to
numerous cellular functions in eukaryotic organisms. In the pathogenic fungus Cryptococcus …

Characteristics of a Regulator of G-Protein Signaling (RGS) rgsC in Aspergillus fumigatus

Y Kim, IB Heo, JH Yu, KS Shin - Frontiers in microbiology, 2017 - frontiersin.org
The regulator of G-protein signaling (RGS) proteins have a conserved RGS domain that
facilitates the intrinsic GTPase activity of an activated Gα subunit of heterotrimeric G protein …

RgsA Attenuates the PKA Signaling, Stress Response, and Virulence in the Human Opportunistic Pathogen Aspergillus fumigatus

HP Lwin, YH Choi, MW Lee, JH Yu… - International Journal of …, 2019 - mdpi.com
The regulator of G-protein signaling (RGS) proteins play an important role in upstream
control of heterotrimeric G-protein signaling pathways. In the genome of the human …

G Protein α Subunit GpaB is Required for Asexual Development, Aflatoxin Biosynthesis and Pathogenicity by Regulating cAMP Signaling in Aspergillus flavus

Y Liu, K Yang, Q Qin, G Lin, T Hu, Z Xu, S Wang - Toxins, 2018 - mdpi.com
The heterotrimeric G proteins are critical for signal transduction and function in numerous
biological processes including vegetative growth, asexual development and fungal …

RgsD negatively controls development, toxigenesis, stress response, and virulence in Aspergillus fumigatus

Y Kim, MW Lee, SC Jun, YH Choi, JH Yu, KS Shin - Scientific Reports, 2019 - nature.com
The regulator of G protein signaling (RGS) domain proteins generally attenuate
heterotrimeric G protein signaling, thereby fine-tune the duration and strength of signal …