Replicative aging of Saccharomyces cerevisiae is an established model system for
eukaryotic cellular aging. A limitation in yeast lifespan studies has been the difficulty of …

Ribosomal RNA gene repeats (rDNA) encode ribosomal RNA, a major component of
ribosomes. Ribosome biogenesis is central to cellular metabolic regulation, and several …

rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known
to be among the most unstable genetic elements due to their repetitive nature. rDNA …

Copy-number changes generate phenotypic variability in health and disease. Whether
organisms protect against copy-number changes is largely unknown. Here, we show that …

Chromatin 3D structure is highly dynamic and associated with many biological processes,
such as cell cycle progression, cellular differentiation, cell fate reprogramming, cancer …

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations
found in humans with genetic disorders. However, there is a lack of genetic engineering …

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide+ (NAD+) dependent enzyme and
stress response protein that has sparked the curiosity of many researchers in different …

The goal of the aging field is to develop novel therapeutic interventions that extend human
health span and reduce the burden of age‐related disease. While organismal aging is a …

Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast
cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S …

The causal relationship between genomic instability and replicative aging is unclear. We
reveal here that genomic instability at the budding yeast ribosomal DNA (rDNA) locus …