The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Cardiovascular disease (CVD) is the most prevalent disease worldwide and there is intense
interest in pharmaceutical approaches to reduce the burden of this chronic, aging-related …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-
dependent deacetylase that removes acetyl groups from various proteins. A wide variety of …

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …

The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide
adenine dinucleotide (NAD+)-dependent histone deacetylases with important roles in …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Calorie restriction is considered to be the best environmental intervention providing health
benefits to mammals. The underlying mechanism of this intervention seems to be controlled …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …