Bioactive isomers of conjugated linoleic acid inhibit the survival of malignant glioblastoma cells but not primary astrocytes

AS Silva‐Ramirez, CG Castillo… - European Journal of …, 2018 - Wiley Online Library
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic
acid (LA), which is reported as anti‐proliferative against glioblastoma (GBM). However, its …

trans-10,cis-12 Conjugated Linoleic Acid Inhibits the G1–S Cell Cycle Progression in DU145 Human Prostate Carcinoma Cells

EJ Kim, HK Shin, JS Cho, SK Lee, MH Won… - Journal of medicinal …, 2006 - liebertpub.com
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic
acid, and has evidenced anti-cancer activities in experimental animal cancer models and in …

Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells

OL Lui, NK Mak, KN Leung - … journal of oncology, 2005 - spandidos-publications.com
Conjugated linoleic acid (CLA) refers to a group of naturally occurring positional and
geometrical conjugated dienoic isomers of linoleic acid (C18: 2), of which the cis-9, trans-11 …

PPARγ‐dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF)

AM Cimini, L Cristiano, S Colafarina… - … Journal of Cancer, 2005 - Wiley Online Library
Conjugated linoleic acid (CLA) has been shown to exert beneficial effects against
carcinogenesis, atherosclerosis and diabetes. It has been demonstrated that CLA modulates …

Downregulation of inflammatory markers by conjugated linoleic acid isomers in human cultured astrocytes

F Saba, A Sirigu, R Pillai, P Caria… - Nutritional …, 2019 - Taylor & Francis
Objectives: Conjugated linoleic acid (CLA) isomers have been shown to possess anti-
inflammatory activity in the central nervous system. In this study, we aimed to evaluate …

Divergent cytotoxic effects of Conjugated linoleic acid isomers on NCI-N87 Cells

SJ Park, CW Park, SJ Kim, JK Kim, YR Kim, YS Kim… - 2003 - ACS Publications
Cytotoxic effects of four conjugated linoleic acid (CLA) isomers (trans-10, cis-12 CLA; cis-9,
trans-11 CLA; trans-10, trans-12 CLA; and trans-9, trans-11 CLA) were evaluated in NCI …

Synthesis and evaluation of cytotoxic activity of conjugated linoleic acid derivatives (esters, alcohols, and their acetates) toward cancer cell lines

N Niezgoda, A Gliszczyńska… - European Journal of …, 2017 - Wiley Online Library
Conjugated linoleic acid (CLA) is natural unsaturated fatty acid known for the wide biological
properties therefore is available in functional food and cosmetics and as a dietary …

[PDF][PDF] Antiproliferative effects of conjugated linoleic acid on human colon adenocarcinoma cell line Caco-2

G Huang, X Zhong, Y Cao, Y Chen - Asia Pac J Clin Nutr, 2007 - apjcn.nhri.org.tw
Conjugated linoleic acid (CLA) reduces body fat reserves, and reduces atherogenesis and
type II diabetes in animal experiments. It has been reported that CLA have isomeric …

Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids

PV Subbaiah, IG Gould, S Lal, B Aizezi - Biochimica et Biophysica Acta …, 2011 - Elsevier
Although the conjugated linoleic acids (CLA) have several isomer-specific biological effects
including anti-carcinogenic and anti-adipogenic effects, their mechanisms of action remain …

Anti-cancer effect of phosphatidylcholine containing conjugated linoleic acid at sn-2 position on MCF-7 breast cancer cell line

RR Fauziah, C Rie, T Yoshino, S Ogita… - Indonesian Journal of …, 2022 - ejournal.kjpupi.id
Conjugated linoleic acid (CLA) exhibits anti-cancer effects; however, most studies have only
investigated its free fatty acid forms (CLA-FFA). Here, we compared the anticancer effect of …