Cacao extract enriched in polyphenols prevents endocrine-metabolic disturbances in a rat model of prediabetes triggered by a sucrose rich diet

MC Castro, H Villagarcia, A Nazar, LG Arbeláez… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Cocoa extracts rich in polyphenols are used as potential
agent for treating diabetes. Cocoa polyphenols have been proved to ameliorate important …

Antidiabetic actions of cocoa flavanols

MÁ Martin, L Goya, S Ramos - Molecular nutrition & food …, 2016 - Wiley Online Library
Prevention of diabetes mellitus type 2 (DMT2) through the diet is receiving a growing interest
and cocoa because of its polyphenolic compounds, mainly flavanols, has become an …

Effects of cocoa antioxidants in type 2 diabetes mellitus

S Ramos, MA Martín, L Goya - Antioxidants, 2017 - mdpi.com
Type 2 Diabetes mellitus (T2D) is the most common form of diabetes and one of the most
common chronic diseases. Control of hyperglycaemia by hypoglycaemic drugs is insufficient …

Alpha-amylase and alpha-glucosidase upregulated glucose homeostasis in high-fat fed wistar rats supplemented with cocoa flavonoid-rich aqueous

YD Igbayilola, MG Gujja - Food Bioscience, 2024 - Elsevier
This study investigates the impact of cocoa (Theobroma Cacao L.) flavonoid-rich aqueous
supplementation on alpha-amylase and alpha-glucosidase enzymes, influencing glucose …

Effects of cocoa extract containing polyphenols and methylxanthines on biochemical parameters of obese‐diabetic rats

AM Mhd Jalil, A Ismail, PP Chong… - Journal of the …, 2009 - Wiley Online Library
BACKGROUND: Previous studies have indicated that cocoa extract possesses
hypoglycaemic and hypocholesterolaemic properties in streptozotocin‐induced diabetic …

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

I Cordero-Herrera, MÁ Martín, F Escrivá… - The journal of nutritional …, 2015 - Elsevier
Insulin resistance is the primary characteristic of type 2 diabetes and results from insulin
signaling defects. Cocoa has been shown to exert anti-diabetic effects by lowering glucose …

Low doses of cocoa extract supplementation ameliorate diet-induced obesity and insulin resistance in rats

P Aranaz, A Romo-Hualde, D Navarro-Herrera… - Food & Function, 2019 - pubs.rsc.org
Cocoa polyphenols exhibit high antioxidant activity and have been proposed as a potential
adjuvant for the treatment of metabolic disturbances. Here, we demonstrate that …

Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats

AMM Jalil, A Ismail, CP Pei, M Hamid… - Journal of agricultural …, 2008 - ACS Publications
In this present study, we investigated the effects of cocoa extract containing polyphenols and
methylxanthines prepared from cocoa powder on the biochemical parameters of obese …

A combination of coffee compounds shows insulin-sensitizing and hepatoprotective effects in a rat model of diet-induced metabolic syndrome

P Shokouh, PB Jeppesen, K Hermansen, NP Nørskov… - Nutrients, 2017 - mdpi.com
Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed
to evaluate the short-and long-term effects of a coffee-based supplement on different …

Combination of aerobic training and cocoa flavanols as effective therapies to reduce metabolic and inflammatory disruptions in insulin-resistant rats: the exercise …

BP Melo, AC Zacarias… - … journal of sport …, 2021 - journals.humankinetics.com
We aimed to investigate the combined effects of aerobic exercise (EXE) and cocoa flavanol
(COCOA) supplementation on performance, metabolic parameters, and inflammatory and …