Precision medicine in pediatric inflammatory bowel disease: an omics and non-omics data-driven patient-centered translational research approach

L Bosa - 2023 - research.unipd.it
Background: Inflammatory bowel disease (IBD) is a spectrum of multifactorial disorders
characterized by dysregulated gut immune response to environmental factors in genetically …

Omes of inflammatory bowel disease: a primer for clinicians

JA Picoraro, NS LeLeiko - Journal of Pediatric Gastroenterology …, 2018 - journals.lww.com
Recent advances in high-throughput laboratory technologies and bioinformatics tools are
redefining how we view inflammatory bowel disease (IBD). Instead of 2 diseases, we now …

[PDF][PDF] Elucidation of novel monogenic disorders in children with intestinal inflammation

D Illig - 2022 - edoc.ub.uni-muenchen.de
Gastrointestinal disorders manifesting with chronic intestinal inflammation are grouped as
inflammatory bowel diseases (IBD). The pathogenesis of IBD is influenced by genetic …

Molecular genetic architecture of monogenic pediatric IBD differs from complex pediatric and adult IBD

G Jezernik, D Mičetić-Turk, U Potočnik - Journal of Personalized …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) manifests as a complex disease resulting from gene–
environment interactions or as a monogenic disease resulting from deleterious mutations …

Genomic and immunologic drivers of very early-onset inflammatory bowel disease

MA Conrad, JR Kelsen - Pediatric and Developmental …, 2019 - journals.sagepub.com
Purpose of Review Inflammatory bowel disease (IBD) is a multifactorial disease caused by
dysregulated immune responses to commensal or pathogenic intestinal microbes, resulting …

the genetics of early onset inflammatory bowel disease (IBD) and diarrheal disorders

A Kurolap, H Baris Feldman - Human Genetics, 2023 - Springer
Inflammatory bowel diseases (IBD) and diarrheal disorders are debilitating conditions
affecting millions of people worldwide. As a whole, these disorders are defined by intestinal …

Mechanisms of pediatric inflammatory bowel disease

JM Peloquin, G Goel, EJ Villablanca… - Annual review of …, 2016 - annualreviews.org
Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is
characterized by chronic intestinal inflammation due to a complex interaction of genetic …

Molecular profiling of inflammatory bowel disease: is it ready for use in clinical decision-making?

HS Lee, I Cleynen - Cells, 2019 - mdpi.com
Inflammatory bowel disease (IBD) is a heterogeneous disorder in terms of age at onset,
clinical phenotypes, severity, disease course, and response to therapy. This underlines the …

Impact of COVID-19 on Pediatric Inflammatory Bowel Diseases—From Expectations to Reality

LM Trandafir, EL Spoiala, G Ghiga, N Gimiga… - Journal of Personalized …, 2024 - mdpi.com
Viral infections have always been considered a threat to global health, with numerous
outbreaks across time. Despite the relative recent experience with coronavirus-associated …

Identification of variants in genes associated with single-gene inflammatory bowel disease by whole-exome sequencing

JJ Ashton, G Andreoletti, T Coelho… - Inflammatory bowel …, 2016 - academic.oup.com
Background Most cases of inflammatory bowel disease (IBD) are caused by complex host–
environment interaction. There are a number of conditions associated with a single-gene …