Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and
neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we …

Wnt/β-catenin (βcat) signaling is critical for adrenal homeostasis. To elucidate how Wnt/βcat
signaling elicits homeostatic maintenance of the adrenal cortex, we characterized the …

The Wnt signaling pathway is a critical mediator of the development and maintenance of
several tissues. The adrenal cortex is highly dependent upon Wnt/β-catenin signaling for …

Prostate cancer development is associated with hyperactive androgen signaling. However,
the molecular link between androgen receptor (AR) function and humoral factors remains …

Signaling by the Wnt family of secreted glycolipoproteins plays key roles in embryonic
development of organisms ranging from nematodes to mammals and is also implicated in …

Genetic studies in mice suggest that Wnt4 signaling antagonizes expression of male
hormones and effectively blocks male development in the female embryo. We recently …

Wnt/β-catenin signalling plays essential roles during embryonic development and in adult
tissue homeostasis. Canonical signalling through Wnt secreted ligands relies on the control …

The androgen receptor (AR) is widely expressed in mammary cells of female mammals
including humans and mice, indicating a possible role for AR-mediated androgen actions in …

The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1) is essential for adrenal
development and regulates genes that specify differentiated adrenocortical function. The …

Testosterone supplementation in men decreases fat mass; however, the mechanisms by
which it inhibits fat mass are unknown. We hypothesized that testosterone inhibits …