Single-cell sequencing: current applications in precision onco-genomics and cancer therapeutics

LM Mustachio, J Roszik - Cancers, 2022 - mdpi.com
Simple Summary Single-cell sequencing technologies are growing, advancing, and
supporting new opportunities to better understand cancer. A variety of technologies are …

Machine learning methods to model multicellular complexity and tissue specificity

RSG Sealfon, AK Wong, OG Troyanskaya - Nature Reviews Materials, 2021 - nature.com
Experimental approaches to study tissue specificity enable insight into the nature and
organization of the cell types and tissues that constitute complex multicellular organisms …

Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes

K Zhang, H Kan, A Mao, L Geng, X Ma - Experimental & molecular …, 2021 - nature.com
Elevated blood pressure caused by excessive salt intake is common and associated with
cardiovascular diseases in most countries. However, the composition and responses of …

An overview on single-cell technology for hepatocellular carcinoma diagnosis

S Aliya, H Lee, M Alhammadi, R Umapathi… - International journal of …, 2022 - mdpi.com
Hepatocellular carcinoma is a primary liver cancer caused by the accumulation of genetic
mutation patterns associated with epidemiological conditions. This lethal malignancy …

Single-cell genomics technology: perspectives

TH Hong, WY Park - Experimental & Molecular Medicine, 2020 - nature.com
In the last decade, molecular and cellular technologies have evolved to give rise to the era
of single-cell genomics, which allows the simultaneous measurement of thousands of genes …

[HTML][HTML] Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models

D Simão, CM Gomes, PM Alves, C Brito - Biotechnology Advances, 2022 - Elsevier
Abstract Advanced three-dimensional (3D) cell models have proven to be capable of
depicting architectural and microenvironmental features of several tissues. By providing data …

Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity

N Kosaji, B Zehra, N Nassir, R Tambi, AR Orszulak… - Med, 2023 - cell.com
Perhaps one of the most revolutionary next generation sequencing technologies is single-
cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the …

Single‑cell multi‑omics advances in lymphoma research

C Jin, D Zhou, J Li, L Bi, L Li - Oncology Reports, 2023 - spandidos-publications.com
The evolution of lymphoma is a multifactorial process that leads to unavoidable lymphoma
heterogeneity in the form of genetic mutations, chromosomal translocations and other …

How a cell decides its own fate: a single-cell view of molecular mechanisms and dynamics of cell-type specification

M Mircea, S Semrau - Biochemical Society Transactions, 2021 - portlandpress.com
On its path from a fertilized egg to one of the many cell types in a multicellular organism, a
cell turns the blank canvas of its early embryonic state into a molecular profile fine-tuned to …

[图书][B] Statistical Simulation and Analysis of Single-cell RNA-seq Data

T Sun - 2023 - search.proquest.com
The recent development of single-cell RNA sequencing (scRNA-seq) technologies has
revolutionized transcriptomic studies by revealing the genome-wide gene expression levels …