SARS-CoV-2, COVID-19 and the aging immune system

JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection

SH Safiabadi Tali, JJ LeBlanc, Z Sadiq… - Clinical microbiology …, 2021 - Am Soc Microbiol
SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and …

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind …

Z Wu, Y Hu, M Xu, Z Chen, W Yang, Z Jiang… - The Lancet Infectious …, 2021 - thelancet.com
Background A vaccine against COVID-19 is urgently needed for older adults, in whom
morbidity and mortality due to the disease are increased. We aimed to assess the safety …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Considering how biological sex impacts immune responses and COVID-19 outcomes

EP Scully, J Haverfield, RL Ursin… - Nature Reviews …, 2020 - nature.com
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants

FK Ho, F Petermann-Rocha, SR Gray, BD Jani… - PloS one, 2020 - journals.plos.org
Introduction Older people have been reported to be at higher risk of COVID-19 mortality.
This study explored the factors mediating this association and whether older age was …

Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats

AM Bosco-Lauth, AE Hartwig… - Proceedings of the …, 2020 - National Acad Sciences
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has reached nearly every country in the world with extraordinary person-to-person …

Pulmonary fibrosis in COVID‐19 survivors: Predictive factors and risk reduction strategies

AS Ojo, SA Balogun, OT Williams… - Pulmonary medicine, 2020 - Wiley Online Library
Although pulmonary fibrosis can occur in the absence of a clear‐cut inciting agent, and
without a clinically clear initial acute inflammatory phase, it is more commonly associated …

Bacterial co‐infections with SARS‐CoV‐2

R Mirzaei, P Goodarzi, M Asadi, A Soltani… - IUBMB …, 2020 - Wiley Online Library
The pandemic coronavirus disease 2019 (COVID‐19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS‐CoV‐2), has affected millions of people worldwide. To …

[HTML][HTML] The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies

LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …