Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

S Zhou, J Liu, A Wan, Y Zhang, X Qi - Journal of Hematology & Oncology, 2024 - Springer
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells
under the action of various physical, chemical and biological factors. The exploration of …

Multi‐omics analysis of disulfidptosis regulators and therapeutic potential reveals glycogen synthase 1 as a disulfidptosis triggering target for triple‐negative breast …

J Xie, X Deng, Y Xie, H Zhu, P Liu, W Deng, L Ning… - MedComm, 2024 - Wiley Online Library
Disruption of disulfide homeostasis during biological processes can have fatal
consequences. Excess disulfides induce cell death in a novel manner, termed as …

A disulfidptosis-related lncRNA index predicting prognosis and the tumor microenvironment in colorectal cancer

L Xiao, W Yin, X Chen, X Zhang, C Zhang, Z Yu… - Scientific Reports, 2023 - nature.com
Colorectal cancer (CRC) is a common and deadly cancer worldwide with a high lethality
rate. Disulfidptosis has been found to be an emerging mode of death in cancer, and the …

The disulfidptosis-related signature predicts prognosis and immune features in glioma patients

X Wang, J Yang, F Yang, K Mu - Scientific Reports, 2023 - nature.com
Glioma is the most common primary malignant tumor in the central nervous system.
Disulfidptosis is a recently identified programmed cell death in tumor cells overexpressing …

Based on disulfidptosis-related glycolytic genes to construct a signature for predicting prognosis and immune infiltration analysis of hepatocellular carcinoma

Z Wang, X Chen, J Zhang, X Chen, J Peng… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) comprises several distinct molecular subtypes
with varying prognostic implications. However, a comprehensive analysis of a prognostic …

Identification of disulfidptosis-related genes and subgroups in Alzheimer's disease

S Ma, D Wang, D Xie - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Background Alzheimer's disease (AD), a common neurological disorder, has no effective
treatment due to its complex pathogenesis. Disulfidptosis, a newly discovered type of cell …

A disulfidptosis-related lncRNA prognostic model to predict survival and response to immunotherapy in lung adenocarcinoma

HB Zhang, JY Pan, T Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and has a
poor prognosis. Disulfidptosis is a novel regulated cell death form characterized by aberrant …

Disulfidptosis-related lncRNA signatures assess immune microenvironment and drug sensitivity in hepatocellular carcinoma

K Xu, C Dai, J Yang, J Xu, C Xia, J Li, C Zhang… - Computers in Biology …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is associated with a high mortality rate, where resistance to
immunotherapy and chemotherapy plays a crucial role. A newly identified form of cell death …

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

J Chen, B Ma, Y Yang, B Wang, J Hao, X Zhou - Biomarker Research, 2024 - Springer
Cell death is an important part of the life cycle, serving as a foundation for both the orderly
development and the maintenance of physiological equilibrium within organisms. This …

Integrated analysis of disulfidptosis-related immune genes signature to boost the efficacy of prognostic prediction in gastric cancer

J Li, T Yu, J Sun, M Ma, Z Zheng, Y He, W Kang… - Cancer Cell …, 2024 - Springer
Background Gastric cancer (GC) remains a malignant tumor with high morbidity and
mortality, accounting for approximately 1,080,000 diagnosed cases and 770,000 deaths …