Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Dysregulation of intercellular communication is a hallmark of aging. To better quantify and
explore changes in intercellular communication, we present scDiffCom and scAgeCom …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

Ageing is a complex and multifactorial process. For two decades, the Human Ageing
Genomic Resources (HAGR) have aided researchers in the study of various aspects of …

DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …

Understanding why we age is a long-standing question, and many mechanistic theories of
aging have been proposed. Owing to limitations in studying the aging process, including a …

Epigenetic aging clocks are computational models that predict age using DNA methylation
information. Initially, first-generation clocks were developed to make predictions using CpGs …