Multidimensional progressive declines in the absence of standard biomarkers for
neurodegeneration are observed commonly in the development of schizophrenia, and are …

It is now possible to estimate an individual's brain age via brain scans and machine-learning
models. This validated technique has opened up new avenues for addressing clinical …

Females live longer than males, and there are sex disparities in physical health and disease
incidence. However, sex differences in biological aging have not been consistently reported …

Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Evidence suggests that psychopathology is associated with an advanced brain ageing
process, typically mapped using machine learning models that predict an individual's age …

Previous studies evaluating the morphology of the selected retinal layers in schizophrenia
showed abnormalities regarding macular thickness, retinal nerve fiber layer (RNLF), and …

Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered
by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated by …

Recent evidence supports accelerated cognitive decline and brain changes in middle-aged
and older people with schizophrenia, relative to the general population. More research in …

Conceptualizing mental disorders as deviations from normative functioning provides a
statistical perspective for understanding the individual heterogeneity underlying psychiatric …