Given the heterogeneity seen in cell populations within biological systems, analysis of single
cells is necessary for studying mechanisms that cannot be identified on a bulk population …

The recent technical and computational advances in single-cell sequencing technologies
have significantly broaden our toolkit to study tumor microenvironment (TME) directly from …

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by
mediating negative selection of autoreactive T cells through the collective expression of the …

Spermatogenesis is a complex process of cellular division and differentiation that begins
with spermatogonia stem cells and leads to functional spermatozoa production. However …

Single-cell sequencing is a biotechnology to sequence one layer of genomic information for
individual cells in a tissue sample. For example, single-cell DNA sequencing is to sequence …

Single-cell RNA sequencing (scRNA-seq) is a new technology that focuses on the
expression levels for each cell to study cell heterogeneity. Thus, new computational …

Background The testis is a complex organ that undergoes extensive developmental
changes from the embryonic stage to adulthood. The development of germ cells, which give …

MECP2, CDKL5, and FMR1 are three X-linked neurodevelopmental genes associated with
Rett, CDKL5-, and fragile-X syndrome, respectively. These syndromes are characterized by …

Autophagy, a critical catabolic process for cell survival against different types of stress, has a
role in the differentiation of various cells, such as cardiomyocytes. Adenosine 5ʹ …

Single cell RNA-sequencing (scRNA-seq) technology has matured to the point that it is
possible to generate large single cell atlases of developing mouse embryos. These atlases …