Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015
incorporated experts from academia, industry, and nonprofit organizations to develop new …

Research programmes on oxidative stress and hormesis are wide ranging. Biomedical and
toxicological sciences have traditionally centralised such research, but in the last years we …

In this review, it is our aim 1) to describe the high diversity in molecular and structural
antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept …

The idea that resources are limited and animals can maximise fitness by trading costly
activities off against one another forms the basis of life-history theory. Although investment in …

Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major
approaches aimed at understanding the organization and dynamics of metabolic networks …

The aging process is accompanied by critical changes in cellular and molecular functions,
which upset the homeostatic balance in the central nervous system. Accumulation of metals …

Plant leaves, harvesting light energy and fixing CO2, are a major source of foods on the
earth. Leaves undergo developmental and physiological shifts during their lifespan, ending …

Highlights•Interconnectivity and homeostatic feedback are fundamental properties of
biological systems.•Specific nodes in the interconnected network of an organism are more …