Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

To the extent that pharmacokinetics influence the effectiveness of nonliving therapeutics, so
too do cellular kinetics influence the efficacy of Chimeric Antigen Receptor (CAR)-T cell …

Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …

The lymphocyte genome is prone to many threats, including programmed mutation during
differentiation, antigen-driven proliferation and residency in diverse microenvironments …

A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of
pathogens, and TCR repertoire size is believed to decline with age. However, the precise …

Memory T cells form an essential part of immunological memory, which can last for years or
even a lifetime. Much experimental work has shown that the individual cells that make up the …

BACKGROUND There is increasing evidence, in transgenic mice and in vitro, that inhibitory
killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses …

More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally
expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level …

Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …

Macrophages' role in the evolution of solid tumours is a well accepted fact, with the M1-like
macrophages having an anti-tumour role and the M2-like macrophages having a pro-tumour …