Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

Y Chen, J Dai, L Tang, T Mikhailova, Q Liang, M Li… - Molecular …, 2023 - nature.com
Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

Experimental models to study immune dysfunction in the pathogenesis of Parkinson's disease

J Saponjic, R Mejías, N Nikolovski, M Dragic… - International journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a chronic, age-related, progressive multisystem disease
associated with neuroinflammation and immune dysfunction. This review discusses the …

Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson's disease

X Zhang, S Xu, Y Hu, Q Liu, C Liu, H Chai… - npj Parkinson's …, 2023 - nature.com
Exercise has been proposed as an effective non-pharmacological management for
Parkinson's disease (PD) patients. Irisin, a recently identified myokine, is increased by …

Identifying crosstalk genetic biomarkers linking a neurodegenerative disease, Parkinson's disease, and periodontitis using integrated bioinformatics analyses

S Hu, S Li, W Ning, X Huang, X Liu, Y Deng… - Frontiers in Aging …, 2022 - frontiersin.org
Objective To identify the genetic linkage mechanisms underlying Parkinson's disease (PD)
and periodontitis, and explore the role of immunology in the crosstalk between both these …

Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples

SC Pike, M Havrda, F Gilli, Z Zhang, LA Salas - npj Parkinson's Disease, 2024 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
United States. Decades before motor symptoms manifest, non-motor symptoms such as …

Infiltration of immune cells to the brain and its relation to the pathogenesis of Alzheimer's and Parkinson's diseases

C Netzahualcoyotzi, JJ Santillán‐Cigales… - Journal of …, 2024 - Wiley Online Library
The neurovascular unit, composed of vascular endothelium, vascular smooth muscle,
extracellular matrix components, pericytes, astrocytes, microglia, and neurons, allows the …

Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson's disease

Q Guan, W Liu, K Mu, Q Hu, J Xie, L Cheng… - Frontiers in …, 2022 - frontiersin.org
Brain infiltration of the natural killer (NK) cells has been observed in several
neurodegenerative disorders, including Parkinson's disease (PD). In a mouse model of α …

Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson's Disease

M Zhang, W Meng, C Liu, H Wang, R Li, Q Wang… - Brain Sciences, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease; it mainly
occurs in the elderly population. Cuproptosis is a newly discovered form of regulated cell …

Novel diagnostic biomarkers related to immune infiltration in Parkinson's disease by bioinformatics analysis

P Zhang, L Zhao, H Li, J Shen, H Li… - Frontiers in Neuroscience, 2023 - frontiersin.org
Background Parkinson's disease (PD) is Pengfei Zhang Liwen Zhao Pengfei Zhang Liwen
Zhao a common neurological disorder involving a complex relationship with immune …

c-KIT inhibitors reduce pathology and improve behavior in the Tg (SwDI) model of Alzheimer's disease

M Stevenson, ML Hebron, X Liu… - Life Science …, 2024 - life-science-alliance.org
Treatments for Alzheimer's disease have primarily focused on removing brain amyloid
plaques to improve cognitive outcomes in patients. We developed small compounds, known …