Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …

Background Accelerated aging leads to increasing burdens of chronic diseases in late life,
posing a huge challenge to the society. With two well-developed aging measures (ie …

Abstract Background Essential trace elements (ETEs) play essential roles in vital functions,
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …

Growing evidence suggests that social relationship quality can influence age-related health
outcomes, although how the quality of one's relationships directly relates to the underlying …

Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older
adults having greater risk. Like other age-related diseases, residents of high-deprivation …

Background & aims The interaction between diet, inflammation, and oxidative stress
significantly influences aging, but the available evidence has been limited. We evaluated …

Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …

By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …