DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4

C Wang, W Ni, Y Yao, A Just, J Heiss, Y Wei, X Gao… - …, 2021 - thelancet.com
Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …

Contribution of life course circumstances to the acceleration of phenotypic and functional aging: a retrospective study

X Cao, C Ma, Z Zheng, L He, M Hao, X Chen… - …, 2022 - thelancet.com
Background Accelerated aging leads to increasing burdens of chronic diseases in late life,
posing a huge challenge to the society. With two well-developed aging measures (ie …

[HTML][HTML] Associations of essential trace elements with epigenetic aging indicators and the potential mediating role of inflammation

X Cheng, Y Wei, R Wang, C Jia, Z Zhang, J An, W Li… - Redox Biology, 2023 - Elsevier
Abstract Background Essential trace elements (ETEs) play essential roles in vital functions,
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …

Social relationships and epigenetic aging in older adulthood: Results from the Health and Retirement Study

KE Rentscher, ET Klopack, EM Crimmins… - Brain, behavior, and …, 2023 - Elsevier
Growing evidence suggests that social relationship quality can influence age-related health
outcomes, although how the quality of one's relationships directly relates to the underlying …

ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age

W Qiu, H Chen, M Kaeberlein, SI Lee - The Lancet Healthy Longevity, 2023 - thelancet.com
Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

[HTML][HTML] Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain

P Jackson, AL Spector, LJ Strath, LH Antoine… - Social Science & …, 2023 - Elsevier
An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older
adults having greater risk. Like other age-related diseases, residents of high-deprivation …

Association of dietary inflammatory potential, dietary oxidative balance score and biological aging

X Wang, L Cheng, K Dang, J Hu, S Pan, J Zhang, X Xu… - Clinical Nutrition, 2024 - Elsevier
Background & aims The interaction between diet, inflammation, and oxidative stress
significantly influences aging, but the available evidence has been limited. We evaluated …

Epigenetic clock and methylation studies in cats

K Raj, B Szladovits, A Haghani, JA Zoller, CZ Li… - GeroScience, 2021 - Springer
Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

Alcohol consumption and methylation-based measures of biological age

JK Kresovich, AM Martinez Lopez… - The Journals of …, 2021 - academic.oup.com
Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …

[HTML][HTML] Sex differences in frailty among older adults

RS Zeidan, T McElroy, L Rathor, MS Martenson… - Experimental …, 2023 - Elsevier
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …