RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …

Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

Background Humoral immunocompetence develops stepwise throughout life and
contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and …

Multiple cornerstones have shaped the history of vaccines, which may contain live-
attenuated viruses, inactivated organisms/viruses, inactivated toxins, or merely segments of …

Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …

Age is associated with altered immune functions that may affect the brain. Brain barriers,
including the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB), are important …

Background Older adults at a higher risk of adverse outcomes and mortality if they get
infected with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …