Bladder cancer in the elderly

SF Shariat, M Milowsky, MJ Droller - Urologic Oncology: Seminars and …, 2009 - Elsevier
INTRODUCTION: Age is now widely accepted as the greatest single risk factor for
developing bladder cancer, and bladder cancer is considered as primarily a disease of the …

Immunoinformatic-based design of immune-boosting multiepitope subunit vaccines against monkeypox virus and validation through molecular dynamics and immune …

M Suleman, F Rashid, S Ali, H Sher, S Luo… - Frontiers in …, 2022 - frontiersin.org
Monkeypox virus is the causative agent of monkeypox disease, belonging to an
orthopoxvirus genus, with a disease pattern similar to that of smallpox. The number of …

[HTML][HTML] Lower vaccine uptake amongst older individuals living alone: A systematic review and meta-analysis of social determinants of vaccine uptake

A Jain, AJ Van Hoek, D Boccia, SL Thomas - Vaccine, 2017 - Elsevier
Introduction Vaccination is a key intervention to reduce infectious disease mortality and
morbidity amongst older individuals. Identifying social factors for vaccine uptake enables …

Gain and loss of T cell subsets in old age—age-related reshaping of the T cell repertoire

CR Arnold, J Wolf, S Brunner… - Journal of clinical …, 2011 - Springer
The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

N Dendouga, M Fochesato, L Lockman, S Mossman… - Vaccine, 2012 - Elsevier
Lack of adequate cell-mediated immunity (CMI) to varicella-zoster virus (VZV) has been
associated with higher risks of developing herpes zoster (HZ) and associated post-herpetic …

Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double‐Blind, Placebo‐Controlled Trial

M Jawad, R Schoop, A Suter, P Klein… - Evidence‐Based …, 2012 - Wiley Online Library
Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract
in the prevention of common cold episodes in a large population over a 4‐month period …

Sex differences in older adults' immune responses to seasonal influenza vaccination

EA Voigt, IG Ovsyannikova, RB Kennedy… - Frontiers in …, 2019 - frontiersin.org
Background: Sex differences in immune responses to influenza vaccine may impact efficacy
across populations. Methods: In a cohort of 138 older adults (50–74 years old), we …

Mechanisms of immunosenescence

C Caruso, S Buffa, G Candore, G Colonna-Romano… - Immunity & …, 2009 - Springer
Abstract On April 7, 8, 2009 a Symposium entitled" Pathophysiology of Successful and
Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn …

Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging

G Del Giudice, JJ Goronzy… - npj Aging and …, 2017 - nature.com
The progressive increase of the aged population worldwide mandates new strategies to
ensure sustained health and well-being with age. The development of better and/or new …

Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation

A Parmigiani, ML Alcaide, R Freguja, S Pallikkuth… - PloS one, 2013 - journals.plos.org
Background Aging and HIV infection are independently associated with excessive immune
activation and impaired immune responses to vaccines, but their relationships have not …