Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis …

G Ayyubova, M Kodali, R Upadhya, LN Madhu… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural
stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating …

Neuroimaging of mouse models of Alzheimer's disease

A Jullienne, MV Trinh, A Obenaus - Biomedicines, 2022 - mdpi.com
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made
great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite …

Medicine-food herbs against alzheimer's disease: A review of their traditional functional features, substance basis, clinical practices and mechanisms of action

P Guo, B Zhang, J Zhao, C Wang, Z Wang, A Liu, G Du - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that currently has
reached epidemic proportions among elderly populations around the world. In China …

Construction and evaluation of Alzheimer's disease diagnostic prediction model based on genes involved in mitophagy

Y Pei, S Chen, F Zhou, T Xie, H Cao - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) is a common neurodegenerative disease. The
concealment of the disease is the difficulty of its prevention and treatment. Previous studies …

Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease

J He, KY Tam - Drug Discovery Today, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that affects over 55 million
patients worldwide. Most of the approved small-molecule drugs for AD have been designed …

Advancing Alzheimer's therapeutics: Exploring the impact of physical exercise in animal models and patients

J Andrade-Guerrero, P Rodríguez-Arellano… - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is the main neurodegenerative disorder characterized by several
pathophysiological features, including the misfolding of the tau protein and the amyloid beta …

[HTML][HTML] Specific serum autoantibodies predict the development and progression of Alzheimer's disease with high accuracy

L Fang, B Jiao, X Liu, Z Wang, P Yuan, H Zhou… - Brain, Behavior, and …, 2024 - Elsevier
Autoimmunity plays a key role in the pathogenesis of Alzheimer's disease (AD). However,
whether autoantibodies in peripheral blood can be used as biomarkers for AD has been …

Unveiling the therapeutic potentials of mushroom bioactive compounds in Alzheimer's disease

N Li, H Li, Z Liu, G Feng, C Shi, Y Wu - Foods, 2023 - mdpi.com
Alzheimer's disease (AD) stands as a prevailing neurodegenerative condition (NDs),
leading to the gradual deterioration of brain cells and subsequent declines in memory …

Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer's disease: a systematic review and meta-analysis

Y Zhang, J Tian, J Ni, M Wei, T Li, J Shi - Frontiers in Pharmacology, 2024 - frontiersin.org
Background: The complexity of Chinese medicine treatment for Alzheimer's disease (AD)
utilizing a multi-herb therapy makes the evidence in current studies insufficient. Herb pairs …

MSC-Derived Extracellular Vesicles Alleviate NLRP3/GSDMD-Mediated Neuroinflammation in Mouse Model of Sporadic Alzheimer's Disease

L Lin, L Huang, S Huang, W Chen, H Huang… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease, with sporadic
form being the predominant type. Neuroinflammation plays a critical role in accelerating …