New approach for early and specific Alzheimer disease diagnosis from different plasma biomarkers

A Forte, S Lara, C Peña-Bautista, M Baquero… - Clinica Chimica …, 2024 - Elsevier
Abstract Background Alzheimer Disease (AD) is a complex pathology, in which several
biochemical pathways could be involved. Therefore, the development of clinical studies …

Acute effects of focused ultrasound-induced blood-brain barrier opening on anti-pyroglu3 abeta antibody delivery and immune responses

P Bathini, T Sun, M Schenk, S Schilling, NJ McDannold… - Biomolecules, 2022 - mdpi.com
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid plaques and hyperphosphorylated tau in the brain. Currently …

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer's disease

S Darvesh, S Banfield, M Dufour… - Journal of Enzyme …, 2023 - Taylor & Francis
Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer
disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have …

Precision medicine in alzheimer's disease: Investigating comorbid common biological substrates in the rat model of amyloid beta-induced toxicity

MG Morgese, M Bove, L Di Cesare Mannelli… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD), one of the most widespread neurodegenerative disorder, is a fatal
global burden for the elder population. Although many efforts have been made, the search of …

Biological and disease hallmarks of Alzheimer's disease defined by Alzheimer's disease genes

S Murakami, P Lacayo - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
An increasing number of genes associated with Alzheimer's disease (AD genes) have been
reported. However, there is a lack of an overview of the genetic relationship between AD …

Advances in diagnosing mild cognitive impairment and Alzheimer's disease using 11C-PIB- PET/CT and common neuropsychological tests

Q Zhao, X Du, W Chen, T Zhang, Z Xu - Frontiers in Neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is a critical health issue worldwide that has a negative impact on
patients' quality of life, as well as on caregivers, society, and the environment. Positron …

Investigation of anti-Alzheimer's mechanisms of sarsasapogenin derivatives by network-based combining structure-based methods

M Zhou, J Sun, Z Yu, Z Wu, W Li, G Liu… - Journal of Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD), a neurodegenerative disease with no cure, affects millions of
people worldwide and has become one of the biggest healthcare challenges. Some …

BNLoop-GAN: a multi-loop generative adversarial model on brain network learning to classify Alzheimer's disease

Y Cao, H Kuai, P Liang, JS Pan, J Yan… - Frontiers in …, 2023 - frontiersin.org
Recent advancements in AI, big data analytics, and magnetic resonance imaging (MRI)
have revolutionized the study of brain diseases such as Alzheimer's Disease (AD). However …

Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults

KP Lopes, L Yu, X Shen, Y Qiu, S Tasaki… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION The secreted phosphoprotein 1 (SPP1) gene expressed by CD11c+ cells
is known to be associated with microglia activation and neuroinflammatory diseases. As …

The Role of Reactive Oxygen Species in Alzheimer's Disease: from Mechanism to Biomaterials Therapy

Z Yu, F Luo - Advanced Healthcare Materials, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic, insidious, and progressive neuro‐degenerative
disease that remains a clinical challenge for society. The fully approved drug lecanemab …