In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1
MT Lv, HC Wang, XW Meng, YT Shi… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims FoxO1 is an important target in the treatment of Alzheimer's disease (AD). However,
FoxO1‐specific agonists and their effects on AD have not yet been reported. This study …
FoxO1‐specific agonists and their effects on AD have not yet been reported. This study …
[HTML][HTML] Schizophrenia: A scientific graveyard or a pragmatically useful diagnostic construct?
EF Walker, DR Goldsmith - Schizophrenia research, 2022 - ncbi.nlm.nih.gov
References to schizophrenia research as a scientific “graveyard” first appeared decades
ago (Plum, 1972). This special issue demonstrates that controversies about the …
ago (Plum, 1972). This special issue demonstrates that controversies about the …
Alterations of spatial memory and gut microbiota composition in alzheimer's disease triple-transgenic mice at 3, 6, and 9 months of age
Z Wei, D Li, J Shi - … Journal of Alzheimer's Disease & Other …, 2023 - journals.sagepub.com
Alzheimer's disease (AD) is a progressive neurological disease. Gut microbial dysbiosis is
associated with AD. This study involves the comparative assessment of spatial learning, β …
associated with AD. This study involves the comparative assessment of spatial learning, β …
Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer's disease: a narrative review
X Jiang, J Li, X Yao, H Ding, A Gu… - Frontiers in Pharmacology, 2024 - frontiersin.org
Insulin resistance in brain and amyloidogenesis are principal pathological features of
diabetes-related cognitive decline and development of Alzheimer's disease (AD). A growing …
diabetes-related cognitive decline and development of Alzheimer's disease (AD). A growing …
The synergistic effect of curcumin and mitoquinol mesylate on cognitive impairment and the neuropathology of Alzheimer's disease
Y Xie, X Li, Q Shi, L Le, C Wang, H Xu, G Wu, X Du… - Brain Research, 2024 - Elsevier
Given the complexity and heterogeneity of Alzheimer's disease (AD) pathology, targeted
monotherapy drugs may not be effective. Therefore, synergistic combination therapy of …
monotherapy drugs may not be effective. Therefore, synergistic combination therapy of …
[HTML][HTML] Attenuated memory impairment and neuroinflammation in Alzheimer's disease by aucubin via the inhibition of ERK-FOS axis
C Wang, X Cui, Z Dong, Y Liu, P Xia, X Wang… - International …, 2024 - Elsevier
Alzheimer's disease (AD) is a degenerative illness accompanied by cognitive and memory
loss. In addition to the widely accepted, convincing amyloid cascade hypothesis, the …
loss. In addition to the widely accepted, convincing amyloid cascade hypothesis, the …
[HTML][HTML] Helix-to-sheet transition of the Aβ42 peptide revealed using an enhanced sampling strategy and Markov state model
H Wen, H Ouyang, H Shang, C Da, T Zhang - Computational and Structural …, 2024 - Elsevier
The self-assembly of Aβ peptides into toxic oligomers and fibrils is the primary cause of
Alzheimer's disease. Moreover, the conformational transition from helix to sheet is …
Alzheimer's disease. Moreover, the conformational transition from helix to sheet is …
Multifactor dimensionality reduction analysis to evaluate the association of dopamine beta-hydroxylase (DΒH) polymorphisms with susceptibility to dementia (SADEM …
T Juárez-Cedillo, N Martínez-Rodríguez… - Molecular …, 2023 - Springer
Dementia is a multifactorial disease in which environmental, lifestyle, and genetic factors
intervene. Population studies have been used in looking for the susceptibility genes for this …
intervene. Population studies have been used in looking for the susceptibility genes for this …
[HTML][HTML] Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway
YL Wang, JG Wang, S Guo, FL Guo, EJ Liu… - Aging and …, 2023 - ncbi.nlm.nih.gov
Neuronal synchronization at gamma frequency (30-100 Hz: γ) is impaired in early-stage
Alzheimer's disease (AD) patients and AD models. Oligomeric Aβ 1-42 caused a …
Alzheimer's disease (AD) patients and AD models. Oligomeric Aβ 1-42 caused a …
Many Paths to Alzheimer's Disease: A Unifying Hypothesis Integrating Biological, Chemical, and Physical Risk Factors
DJ Lehmann, A Elshorbagy… - Journal of Alzheimer's …, 2023 - content.iospress.com
Sporadic Alzheimer's disease (AD) is a complex, multifactorial disease. We should therefore
expect to find many factors involved in its causation. The known neuropathology seen at …
expect to find many factors involved in its causation. The known neuropathology seen at …