eXplainable Artificial Intelligence (XAI) in aging clock models

A Kalyakulina, I Yusipov, A Moskalev… - Ageing Research …, 2023 - Elsevier
XAI is a rapidly progressing field of machine learning, aiming to unravel the predictions of
complex models. XAI is especially required in sensitive applications, eg in health care, when …

Causality-enriched epigenetic age uncouples damage and adaptation

K Ying, H Liu, AE Tarkhov, MC Sadler, AT Lu, M Moqri… - Nature Aging, 2024 - nature.com
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Application of AI in biological age prediction

D Meng, S Zhang, Y Huang, K Mao, JDJ Han - Current Opinion in Structural …, 2024 - Elsevier
The development of anti-aging interventions requires quantitative measurement of biological
age. Machine learning models, known as “aging clocks,” are built by leveraging diverse …

PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery

P Kamya, IV Ozerov, FW Pun, K Tretina… - Journal of Chemical …, 2024 - ACS Publications
PandaOmics is a cloud-based software platform that applies artificial intelligence and
bioinformatics techniques to multimodal omics and biomedical text data for therapeutic …

[HTML][HTML] Leveraging AI to identify dual-purpose aging and disease targets

GHD Leung, CW Wong, FW Pun, A Aliper… - Expert Opinion on …, 2023 - Taylor & Francis
Aging is a significant contributor to various chronic diseases, thus emerging as an
increasingly important area of research. Elucidating the mechanisms underlying aging can …

eXplainable Artificial Intelligence (XAI) in age prediction: A systematic review

A Kalyakulina, I Yusipov - arXiv preprint arXiv:2307.13704, 2023 - arxiv.org
eXplainable Artificial Intelligence (XAI) is now an important and essential part of machine
learning, allowing to explain the predictions of complex models. XAI is especially required in …

Comprehensive review of Transformer‐based models in neuroscience, neurology, and psychiatry

S Cong, H Wang, Y Zhou, Z Wang, X Yao, C Yang - Brain‐X, 2024 - Wiley Online Library
This comprehensive review aims to clarify the growing impact of Transformer‐based models
in the fields of neuroscience, neurology, and psychiatry. Originally developed as a solution …

ComputAgeBench: Epigenetic Aging Clocks Benchmark

D Kriukov, E Efimov, EA Kuzmina, EE Khrameeva… - bioRxiv, 2024 - biorxiv.org
The success of clinical trials of longevity drugs relies heavily on identifying integrative health
and aging biomarkers, such as biological age. Epigenetic aging clocks predict the biological …