Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

The combination of spatial transcriptomics (ST) and single cell RNA sequencing (scRNA-
seq) acts as a pivotal component to bridge the pathological phenomes of human tissues with …

Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency
continuum in vivo. Previous studies have generated a number of PSCs with distinct …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …