Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
A complex systems approach to aging biology
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …
aging biology research is now moving toward integration of these parts, attempting to …
Empagliflozin improves cognitive impairment in frail older adults with type 2 diabetes and heart failure with preserved ejection fraction
P Mone, A Lombardi, J Gambardella, A Pansini… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To assess whether the sodium–glucose cotransporter 2 (SGLT2) inhibitor
empagliflozin improves cognitive impairment in frail older adults with diabetes and heart …
empagliflozin improves cognitive impairment in frail older adults with diabetes and heart …
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
DB Rosoff, LA Mavromatis, AS Bell, J Wagner, J Jung… - Nature aging, 2023 - nature.com
The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
Frailty, lifestyle, genetics and dementia risk
Objective To optimise dementia prevention strategies, we must understand the complex
relationships between lifestyle behaviours, frailty and genetics. Methods We explored …
relationships between lifestyle behaviours, frailty and genetics. Methods We explored …
The frailty index based on laboratory test data as a tool to investigate the impact of frailty on health outcomes: a systematic review and meta-analysis
DG Sapp, BM Cormier, K Rockwood… - Age and …, 2023 - academic.oup.com
The frailty index (FI) quantifies frailty as deficit accumulation. It has been adapted to employ
laboratory test data (FI-Lab). Our objective was to systematically review and meta-analyse …
laboratory test data (FI-Lab). Our objective was to systematically review and meta-analyse …
Frailty and solid-organ transplant candidates: a scoping review
Background There is currently no consensus as to a standardized tool for frailty
measurement in any patient population. In the solid-organ transplantation population …
measurement in any patient population. In the solid-organ transplantation population …
[HTML][HTML] Frailty and cytokines in preclinical models: Comparisons with humans
Chronic low-grade elevations of blood-borne cytokines/chemokines in older age tend to
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …
How to construct a frailty index from an existing dataset in 10 steps
Background The frailty index is commonly used in research and clinical practice to quantify
health. Using a health deficit accumulation model, a frailty index can be calculated …
health. Using a health deficit accumulation model, a frailty index can be calculated …
Assessment of Frailty Index at 66 years of Age and Association with Age-Related diseases, disability, and Death over 10 years in Korea
Importance A frailty index has been proposed as a measure of aging among older
individuals. However, few studies have examined whether a frailty index measured at the …
individuals. However, few studies have examined whether a frailty index measured at the …